2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W653885
    rac 3,4-Dihydroxymandelic Acid-d3
    rac 3,4-Dihydroxymandelic Acid-d3 is deuterium labeled 3,4-Dihydroxymandelic acid. 3,4-Dihydroxymandelic acid is a metabolite of norepinephrine.
    rac 3,4-Dihydroxymandelic Acid-</sub>d<sub>3</sub>
  • HY-N10403R
    4-Hydroxyestradiol (Standard)
    ABZ-amine (Standard) is the analytical standard of ABZ-amine. This product is intended for research and analytical applications. ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations.
    4-Hydroxyestradiol (Standard)
  • HY-126852
    4-Hydroxy Atorvastatin lactone
    4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
    4-Hydroxy Atorvastatin lactone
  • HY-W100784
    2,6-Dimethylphenylthiourea
    		99.81%
    2,6-Dimethylphenylthiourea is a Xylazine metabolite. Xylazine is the first and most widely used α2-agonist.
    2,6-Dimethylphenylthiourea
  • HY-131964R
    Imidacloprid-urea (Standard)
    Sodium ethylparaben (Standard) is the analytical standard of Sodium ethylparaben. This product is intended for research and analytical applications. Sodium ethylparaben (Sodium ethyl 4-hydroxybenzoate) acts as a water soluble antiseptic usually employed as safe for cosmetics.
    Imidacloprid-urea (Standard)
  • HY-133675S
    Mono(5-carboxy-2-ethylpentyl) phthalate-d4
    Mono(5-carboxy-2-ethylpentyl) phthalate-d4 (MECPP-d4) is a deuterium labeled Mono(5-carboxy-2-ethylpentyl) phthalate (HY-133675). Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(5-carboxy-2-ethylpentyl) phthalate-d<sub>4</sub>
  • HY-135387
    4-Desmethyl Istradefylline
    4-Desmethyl Istradefylline is a metabolite of Istradefylline. 4-Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
    4-Desmethyl Istradefylline
  • HY-W015788R
    1-Phenylethane-1,2-diol (Standard)
    1-Phenylethane-1,2-diol (Standard) is the analytical standard of 1-Phenylethane-1,2-diol. This product is intended for research and analytical applications. 1-Phenylethane-1,2-diol (Styrene Glycol) is a benzyl diol compound, which is the major metabolite of Styrene. 1-Phenylethane-1,2-diol can be oxidized to hydroxyl ketone (2-hydroxy-1-phenylethan-1-one) selectively with variety of catalysts, including organocatalysts, metal complexes, non-noble metal oxides, bimetallics[1][2][3].
    1-Phenylethane-1,2-diol (Standard)
  • HY-W704031
    Prasugrel metabolite 1
    Prasugrel metabolite 1 (M7 (R-119251)) is one of the inactive metabolites of Prasugrel (HY-15284) in the human body.
    Prasugrel metabolite 1
  • HY-W743473
    Cefetamet-d3
    Cefetamet-d3 (Ro 15-8074-d3; Deacetoxycefotaxime-d3) is the deuterium labeled Cefetamet (HY-A0111). Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.
    Cefetamet-d<sub>3</sub>
  • HY-W856819
    Eseroline
    Eseroline is a potent μ-opioid receptor agonist, which is the hydrolytic metabolite of Physostigmine (HY-N6608). Eseroline is a selective and competitive acetylcholinesterase (AChE) inhibitor, with its Ki values for AChE and BuChE being 0.1 μM and 200 μM respectively. Eseroline has nicotinic acetylcholine receptor allosteric enhancing ligand (nAChR-APL) activity, meaning it does not activate the receptor but significantly enhances the signal transduction of Ach triggered by the receptor. Eseroline is neurotoxic, causing cell membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Eseroline can be used for the study of Alzheimer's disease.
    Eseroline
  • HY-131466R
    N-Methyl Palbociclib (Standard)
    Hydroxyurea (Standard) is the analytical standard of Hydroxyurea. This product is intended for research and analytical applications. Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity.
    N-Methyl Palbociclib (Standard)
  • HY-W700643
    Di-N-desethyl amiodarone hydrochloride
    Di-N-desethyl Amiodarone hydrochloride is a metabolite of Amiodarone (HY-14187). Di-N-desethyl Amiodarone hydrochloride is a strong inhibitor of the respiratory chain.
    Di-N-desethyl amiodarone hydrochloride
  • HY-129903
    N-Desethyl vardenafil
    N-Desethyl vardenafil is the major metabolite of Vardenafil (HY-B0442) and can be detected in human urine.
    N-Desethyl vardenafil
  • HY-118614R
    β-Nicotyrine (Standard)
    β-Nicotyrine (Standard) is the analytical standard of β-Nicotyrine. This product is intended for research and analytical applications. β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid.
    β-Nicotyrine (Standard)
  • HY-121745
    Phosmet oxon
    Phosmet oxon (Imidoxon) is a main and toxic metabolite of phosmet. Phosmet is a cholinesterase inhibitor insecticide used on pome and stone fruits.
    Phosmet oxon
  • HY-138627B
    AST5902 mesylate
    AST5902 mesylate is a principal metabolite of Alflutinib, exhibiting significant antineoplastic activity. AST5902 mesylate contributes to the overall pharmacological effects in the treatment of non-small cell lung cancer. AST5902 mesylate is involved in the response to activating EGFR mutations and can help overcome EGFR T790M drug-resistant mutations.
    AST5902 mesylate
  • HY-143712S1
    Allolithocholic Acid-d4
    Allolithocholic Acid-d4 (3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease.
    Allolithocholic Acid-d<sub>4</sub>
  • HY-131261
    Ibuprofen alcohol
    Ibuprofen alcohol, a nonsteroidal antiinflammatory agent (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs).
    Ibuprofen alcohol
  • HY-135910R
    3,4-Dehydro Cilostazol (Standard)
    3,4-Dehydro Cilostazol (Standard) is the analytical standard of 3,4-Dehydro Cilostazol. This product is intended for research and analytical applications. 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study.
    3,4-Dehydro Cilostazol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity